This is a summary list of all laboratories at Oregon Health and Science University . The list includes links to more detailed information, which may also be found using the eagle-i search app.
Aaron M. Cohen is an an associate professor in OHSU's Department of Medical Informatics and Clinical Epidemiology. His research interests focus on the development and application of text-mining techniques and tools for biomedical researchers. He applies information retrieval and machine learning techniques to scientific literature and databases to help researchers to more effectively use and explore the ever-expanding biomedical literature. Aaron received an M.D. from the University of Michigan, and holds a master's degree in biomedical informatics from OHSU. Current projects include the use of automated classification systems in the process of creating systematic drug reviews, and the development and evaluation of computer assisted biomedical question answering systems.
The Vinson Lab is focused on developing large genotyped and phenotyped pedigrees of rhesus macaques in order to study the genetic basis of complex diseases that severely impact the health of both macaques and humans. These diseases include cardiovascular disease and obesity in humans, and endometriosis and colitis in macaques, among others. To characterize the genetic basis of these diseases, they apply quantitative genetic approaches to estimate the heritability of risk factors for disease, to locate quantitative trait loci (QTLs) that influence these risk factors, and to identify functional genetic variants at identified QTLs. They have a particular interest in genetic effects on chronic inflammation and how these effects contribute to increased cardiovascular risk.
Based on a subset of >750 macaques sampled to date, they have recently demonstrated significant heritability for total cholesterol, LDL cholesterol, triglycerides, abdominal circumference, and BMI in a single extended pedigree containing ~1,300 animals spanning 6 generations. Currently, they are working to develop genome-wide genetic data in these pedigreed macaques that will enable a search for QTLs that influence these cardiovascular risk factors, as well as risk factors for other important diseases.
Current Research Goals:
To determine the role of contact activation in acute intraluminal thrombus propagation using synthetic vascular grafts in a primate model of thrombosis and hemostasis. If the functionality of the contact system enzyme complex (FXI/FXII/KK/HMWK) is relevant to the pathogenesis of thrombosis, a FXI inhibitor could become the first safe antithrombotic agent.
To characterize the effects of endogenous protein C activation on acute arterial thrombogenesis and hemostasis using rationally engineered recombinant enzymes. A pharmacologically viable protein C activator could help utilize the body's own antithrombotic and antiinflammatory system similar to the way streptokinase and tPA became useful fibrinolysis activators.
My lab is interested in understanding the changes that occur in the cardiac innervation following ischemia reperfusion (a heart attack). Alterations in the sympathetic innervation of the heart after myocardial infarction can trigger arrhythmias and sudden cardiac death. These neuronal changes are not well understood, but blocking cardiac receptors for the neurotransmitter norepinephrine (NE) can help prevent arrhythmias. We are trying to understand the molecular basis for these changes in noradrenergic function, investigating the regulation of neuronal proteins that synthesize, store, and remove NE, and the genes that encode them. We are also examining the induction of neuropeptides in the cardiac innervation following infarction, and how those peptides alter neurotransmission and cardiac function. Finally, we are examining the role of neurotrophins in post-infarct denervation and nerve sprouting. Cardiac nerve sprouting in humans has been directly linked to cardiac pathology and sudden cardiac death. We use a variety of molecular, biochemical, and histological techniques to investigate the regulation of these proteins and genes, using cell lines, primary neuronal cultures, and whole animal studies.
The Oregon National Primate Research Center is one of 8 centers in the United States that supports non-human primate breeding and research. Our lab is committed to developing the genetic tools and resources necessary for the improved understanding of macaques, both in domestic breeding facilities and in international field settings. The current focus involves the use of single nucleotide polymorphisms (SNPs) for sub-species comparisons and for tracking phenotypes unique to certain populations.
We also have extensive medical histories of hundreds of captive rhesus macaques available to us. These records, in combination with the large family pedigrees produced within the breeding colonies, allow us to genetically analyze quantitative traits of interest. Currently we are studying traits commonly found in rhesus macaques, including macular degeneration, resistance to viral diseases, diabetes, as well a variety of behavioral traits. These research efforts involve interactive collaborations with numerous investigators, both at the OHSU and at other universities.
We are interested in how bones grow. More precisely, we want to understand the molecular and cellular mechanisms that control mammalian skeletal development, especially those involved in linear bone growth. Skeletal growth is primarily responsible for the final form of adult mammals. This is achieved for most bones through the generation of cartilage models that serve as a templates for bone growth, a process known as endochondral ossification. Once the embryonic bone is formed, endochondral ossification occurs near the ends of bones in so called growth plates .
The growth plate is a dynamic structure with a leading edge where new cells arise through mitosis, intermediate zones where terminally differentiatng cells synthesize matrix and facilitate its maturation into a functional template and a trailing edge where the template is degraded and replaced by bone. The synthesis of template, chondrogenesis, drives this process to a large extent.
A large number of genes must be involved in regulating these events judging from the many inherited human disorders (the chondrodysplasias) manifesting defective bone growth, as well as, the many naturally occurring skeletal mutants in mice and other species. However, there must also be much redundancy considering the many man-made misexpression and knockout mouse mutants that exhibit no abnormalities of skeletal development despite disrupting expression of genes that influence basic cell functions such as mitosis and differentiation. Our goal is to understand what the critical genes are and how they work to control the proliferation, survival and terminal differentiation of growth plate chondrocytes. Our experimental approach utilizes a wide variety of biochemical, molecular genetic, immunologic, molecular biology and cell biology methods. It is hoped our results will provide insight into the fundamental biologic process of growth and also establish a rational basis for new therapies for patients with bone growth disorders.
We are examining cell-cell and cell-matrix interactions and intercellular and intracellular signaling pathways that stem cells use during differentiation. These studies aim to increasing understanding of stem cell differentiation into chondrocytes. We are studying this process in vivo and with mesenchymal progenitor and stem cells of various sources in the in vitro chondrogenesis systems developed by our laboratory.
The long-term goal of our research is to understand the functional properties of SCN neurons and how the circadian clock regulates these properties. To reach this goal we are pursuing four lines of research:
Cellular electrophysiology of the suprachiasmatic nucleus
Regulation of retinal input to the SCN
Role of intracellular Ca2+ as a signaling molecule in the circadian system
Characterization of the retinal ganglion cells projecting to the SCN
My laboratory is mainly involved in investigating electron microscopic/immunocytochemical changes in synapses within the brain following various drug treatment procedures or lesions of the nigrostriatal pathway, as a model for Parkinson’s disease (PD), and correlating these findings with functional/protein changes using in vivo microdialysis/westerns and motor behaviors in both rats and mice. Using a new progressive mouse model of PD, by administering increased doses of the toxin, MPTP, we have found that exposure of mice to a socially enriched environment can, after the initiation of the loss of dopamine, slow down or block the neurochemical and motor behavioral deficits due to continued treatment with MPTP. We are currently investigating the therapeutic affects of treadmill exercise in this same progressive MPTP model of PD in both young and aged mice.
My research goal is to obtain an integrated understanding of the steroid-sensitive brain circuitry, neurochemical mechanisms, and the subcellular signaling pathways that mediate the central actions of androgens. A major research focus is the characterization of the aromatase-signaling pathway in neural tissue. Aromatase is a cytochrome P450 enzyme (CYP 19) that catalyzes the conversion of testosterone to estradiol. Although androgens and brain-derived estrogens are believed to act coordinately to regulate brain function, the challenge is to understand the complexity of this interaction at a subcellular, cellular, and systems level. A second research direction in my laboratory aims to understand the cellular mechanism(s) by which herbal preparations inhibit prostate growth and to explore their potential as viable treatments for prostate carcinoma.
My major research interest is investigating the basic cellular and molecular mechanisms of how tumors form and respond to treatment. By studying how these things work, I hope to find specific molecules that are targets for new cancer treatments. I see patients with gastrointestinal (digestive system) cancers and participate in clinical trials for a variety of gastrointestinal cancers.
Research interests include:
Neuroethology, molecular neuroscience, vocal communication, vocal learning, central auditory processing, learning and memory, neurogenomics, neuronal and synaptic plasticity, activity-dependent gene regulation, avian physiology, comparative neuiroscience, sex steroid actions on the brain and behavior, adult neurogenesis.
Our mission is to support all research that may improve the lives of our patients and the quality of the care we provide to them at OHSU Doernbecher Children’s Hospital.
Gamma-prime fibrinogen is an isoform of the blood clotting factor fibrinogen that is a newly-emerging cardiovacular disease risk factor. This application's long- term goal is to elucidate the genetic regulation of gamma-prime fibrinogen as a foundation for understanding its role in cardiovascular disease.
The Lewinsohn laboratory is focused on understanding the mechanisms by which human CD8+ T cells recognize cell infected with Mycobacterium tuberculosis (Mtb), the bacteria responsible for tuberculosis. Areas of interest within the laboratory include:
1) Defining the repertoire of immunodominant antigens in Mtb. Here, we have focused on antigens that are presented by classical HLA molecules (HLA-A, B, and C) as well as those presented by non-classical molecules such has HLA-E.
2) Defining the mechanisms by which Mtb-antigens can enter the HLA-I antigen processing pathway. Because Mtb is an organisms normally found within the phagosome (traditionally a HLA-II processing compartment). We are currently focused on the role of the phagosome as a HLA-I processing compartment.
3) Defining the mechanisms by which innate T cells can recognize those cells infected with Mtb. Here, early recognition of these cells might directly limit intracellular replication of Mtb, or might promote the development of an effective adaptive immune response.
My lab is primarily interested in intracellular signaling pathways in the nervous system with a specific focus on the messenger, cyclic GMP. Cyclic GMP has been shown to regulate diverse physiological functions including phototransduction, smooth muscle tone, water balance and ion fluxes and neuronal plasticity. Cyclic GMP is synthesized by the enzyme guanylyl cyclase (GC) of which there are two major families: cytoplasmically localized soluble GCs (sGCs) and membrane associated receptor GCs (rGCs). Activation of these enzymes, and hence an increase in cellular cyclic GMP concentrations, is achieved by two very different mechanisms. Soluble GCs are heterodimeric proteins that bind a heme prosthetic group and can be activated by free radical messengers such as the gas nitric oxide (NO) that can act as both an intra- and inter-cellular messenger. Receptor GCs, by contrast, are activated by extracellular ligands - usually peptide hormones - by binding to the extracellular portion of the protein.
We have been using an insect, Manduca sexta, for several years as a model for cyclic GMP function and have shown that a neuropeptide, eclosion hormone, elevates cyclic GMP in a neurohemal organ associated with the nervous system. As part of our efforts to elucidate the pathway by which eclosion hormone elevates cyclic GMP we have cloned several different GCs from the CNS of Manduca. In addition to examples of both classic sGCs and rGCs we have also cloned two novel GCs, which don't fit into the usual classification. One of these, MsGC-b3, is closely related to NO-sensitive heterodimeric sGCs, but we have shown that it does not need to form a heterodimer to synthesize cyclic GMP and is insensitive to NO. The other novel GC, MsGC-I, is most closely related to rGCs, but lacks an extracellular ligand-binding domain and hence cannot be activated by extracellular hormones. Our current research is aimed at understanding the regulation and function of these novel signal transduction enzymes.
Recently, we have also begun to use two new model systems, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster, to study GC function and regulation. The published sequence of the C. elegans genome reveals that it has 7 sGCs, yet no NO synthase, suggesting that it cannot use this messenger to activate cGMP production. The Drosophila genome also contains several novel GCs including one that is likely to be the homologue of MsGC-b3. By using genetic manipulations in these organisms we hope to understand how this novel signaling pathway is regulated and what physiological functions it serves.
The focus of the Boison laboratory is the brain’s endogenous anticonvulsant and neuroprotectant adenosine. They try to understand how adenosine function and dysfunction contributes to normal and pathological brain function, respectively, and to translate these findings into novel therapeutic approaches. They study adenosine-related physiological and pathophysiological mechanisms in rodent models of disease and in mice with engineered mutations in adenosine metabolism or signaling. Bioengineered polymers, stem cell therapies, and gene therapies are used to afford therapeutic augmentation of the adenosine system. They apply these tools to study disease mechanisms and treatment options in epilepsy, traumatic brain injury, stroke, and schizophrenia.
To analyze our "neurodegenerative" flies, we are using diverse imaging techniques ranging from live cell imaging to electron microscopy, in addition to molecular and behavioral assays.
Eilis A. Boudreau is an assistant professor in OHSU’s Department of Medical Informatics and Clinical Epidemiology. She also holds appointments in OHSU’s Department of Neurology and at the Portland VA Medical Center as a staff physician working in the sleep medicine and epilepsy programs. She studies sleep and circadian rhythm influences on the development of alcoholism using imaging techniques such as functional magnetic resonance imaging (fMRI) and optical microangiography. She holds a Ph.D. in Biophysics from Syracuse University and an MD from the SUNY Health Science University at Syracuse.
Educational and clinical informatics projects for the Department of Anesthesiology & Perioperative Medicine at OHSU.
AIDS vaccine development, HIV/SIV pathogenesis
Research in Dr. Urbanski's laboratory is focused on two major hypothalamic neural circuits: (1) those responsible for maintaining rhythmic biological functions (e.g., circadian hormone rhythms and the sleep-wake cycle), and (2) those responsible for maintaining normal reproductive function (e.g., puberty, ovulation, and menopause). His primary goal is to elucidate the molecular and cellular mechanisms that underlie these physiological functions, and to understand how they are influenced by various hormones and by changes in the external environment.
Current research projects include several neurologically focused projects (quantitative characterization of prosody in autism, instrumental approaches to neurogenic speech disorders, automated neuropsychological assessment), as well as basic speech technology research.
Research in our laboratory includes microarray analysis of human and nonhuman primate cells, inmmunohistochemistry and molecular approaches to study the effects of gene transfection on steroid hormone-mediated signal transduction, and whole animal studies to study the effects of the ovary and ovarian factors on the OSE ovarian surface epithelium, and the effects of the OSE on the ovary itself.
Dr. Rosenbaum's clinical interests include uveitis and autoimmune disease. His research interests include uveitis, cytokines, leukocyte and endothelial interactions. He currently heads the Uveitis Clinic and is the director of Inflammatory Research at OHSU. Dr. Rosenbaum is the Division Chief of Arthritis and Rheumatic Diseases. He is the Edward E. Rosenbaum Professor of Inflammatory Diseases. Dr. Rosenbaum received his medical degree in 1975 from Yale Medical School in New Haven, CT. He completed his Medicine residency and Rheumatology fellowship at Stanford Medical Center in Stanford, CA.
Small-conductance calcium-activated potassium channels (SK channels) are gated solely by intracellular Ca2+ ions and are fundamental regulators of neuronal excitability. Our laboratory cloned the SK channel family and currently focuses on two main areas.
First, we are investigating the physiological roles of SK channels in hippocampus.
Second, the laboratory is testing the hypothesis that a given subtype of SK channel can serve multiple roles in the same neuron by differential subcellular localization and interactions with distinct sets of microdomain partner proteins, forming an array of Ca2+ signaling complexes.
The Sacha Laboratory is located in the Vaccine & Gene Therapy Institute and Oregon National Primate Research Center at the Oregon Health & Science University. We are a dedicated team of scientists investigating protective immunity to retroviruses in order to develop a prophylactic HIV vaccine.
Research interests center around the secondary use of clinical data for research, with attention on user interfaces, underlying controlled vocabularies, and data structures.
My program of research focuses on family care experiences of chronic illness in an older adult with an emphasis on psychological and relational issues. In particular, I am very interested in balancing the needs of both members of the care dyad throughout the illness trajectory, and how incongruence between patient and family member impacts care transitions and the health and well-being of both members. I have published in the areas of family care and family relationships, most notably the interface between family and formal service use, dyadic incongruence in the care situation, the effects of changing physical and mental health on relationship quality in the care dyad, and early-warning signs in predicting long-term health, depression, and strain of Parkinson’s disease spouses. My current research examines symptom incongruence, communication, decision-making, and family relationships in both end-of-life and chronic illness contexts, involving both care dyads and couples.
Lab research interests:
-Animal models of alcohol abuse and alcoholism
-Sex differences in risk for and consequences of alcohol consumption
-Behavioral Pharmacology of alcohol
-In vivo imaging of alcohol effects on brain development of non human primates
-Genetic and behavioral datasets related to alcohol abuse and alcoholism
Dr. Muldoon has extensive background in tumor and cell biology, magnetic resonance imaging, and histological and immunological methods for assessing neurotoxicity and tumor volumetrics. She has played a central role in the analysis of chemoprotective agents against chemotherapy toxicity, and the development and imaging of brain tumor models.
The Coussens lab focuses on the role of immune cells and their mediators as critical regulators of cancer development. During the early development of cancer, many physiological processes occur in the vicinity of 'young tumor cells' that are similar to processes that occur during embryonic development and to healing of wounds in adult tissue, e.g., leukocyte recruitment and activation (inflammation), angiogenesis (development of new blood supply) and tissue remodeling. During tumor development however, instead of initiating a 'healing' response, activated leukocytes provide growth-promoting factors that typically help tumors grow. We are interested in understanding the molecular and cellular mechanisms that regulate leukocyte recruitment into neoplastic tissue, and the subsequent regulation those leukocytes exert on evolving cancer cells. To address these issues, we have taken several approaches to investigate mechanisms involved in: i. induction and maintenance of chronic inflammatory microenvironments in premalignant, malignant and metastatic tissues using murine models of human cancer development, and clinical samples obtained fresh from the operating room from patients with cancer, ii. role of leukocytes in regulating tissue remodeling, angiogenesis, immune suppression and cancer development, iii. development of novel non-invasive imaging reagents to monitor immune response in tissues/tumors. The long-term goal of this work is to translate basic observations made in the mouse, toward rational design of novel therapeutics whose aim will be to block and/or alter rate-limiting events critical for solid tumor growth, maintenance or recurrence in humans, and/or therapeutics that enhance the efficacy of standard-of-care cytotoxic therapy. Currently, we are actively utilizing transgenic mouse models of solid tumor development (non-small cell lung cancer, non-melanoma squamous, pancreatic and breast adenocarcinoma, and mesothelioma) to reveal the functional roles of adaptive and innate leukocytes during tumor development. These experimental studies are conducted in parallel with evaluation of representative human cancer specimens to affirm that mechanisms revealed in the experimental setting represent fundamental parameters of multi-stage cancer development in humans.
Mark Slifka and his colleagues are investigating the underlying mechanisms of humoral and cell-mediated immunity against acute and chronic viral infections. This work has included developing several models of viral infection and/or vaccination in order to address basic immunological questions related to the development and maintenance of long-term protective immunity. We have also developed a series of clinical studies in which we study immunological memory directly in human subjects. During the course of this work, we study a number of viruses including arenaviruses (lymphocytic choriomeningitis virus, LCMV), alphaviruses (chikungunya virus), flaviviruses (West Nile virus, yellow fever, and dengue), and orthopoxviruses (vaccinia, cowpox, and monkeypox). Several of these viruses cause encephalitis or meningitis (e.g., LCMV, West Nile Virus, and vaccine strains of yellow fever virus) and one of our goals is to develop better vaccines against encephalitic viruses. The combination of basic research in animal models and applied research in clinical studies involving both healthy and immunocompromised populations has provided the opportunity to better define the requirements for immunological memory and to learn how to develop more effective diagnostics and vaccine candidates.
These experiments lay the foundation for future studies in which Slifka and team members will develop new antiviral vaccines and determine the mechanisms involved with building strong vaccine-induced immunity. For instance, these scientists have recently discovered a new hydrogen peroxide-based approach to vaccine production that results in a safer, more effective vaccine preparation that can be used to create better human and animal vaccines.
Research interests include: Anaerobiosis of Bacillus subtilis; oxygen-controlled gene regulation; two-component signal transduction system; transcriptional activation; nitrate/nitrite reductases; flavohemoglobin; anaerobic electron transport; nitric oxide signaling.
I am interested in the mechanisms of abnormal gene inactivation and the relevance of these events to cancer. Abnormal gene inactivation results from two distinct types of events. The first is DNA mutation, which represents a change in the structure of DNA that alters expression of a given gene. The second type of event is epigenetic silencing, which involves loss of gene expression without alteration of the gene sequence. With regards to mutational events, we are interested in both endogenous and exogenous genotoxins that can affect the frequency and types of mutations that occur within the animal. A current focus is on how accelerated particles in space cause large-scale genomic damage that could affect astronauts during prolonged space travel. Our work with epigenetic silencing focuses on how silencing is initiated and determining the pathways that cause active genes to become aberrantly turned off.
Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.
Coordinated muscular contraction and movement is one of the primary functions of the central nervous system (CNS). Sensory information from several sensory systems is integrated with learned motor patterns to guide the limbs, head and trunk through space. The research carried out in my laboratory focuses on how the kinematics of movement are represented in sensory input and how this input is used by the CNS to coordinate muscle contraction. Accordingly, the experimental techniques employed in our studies include electrophysiology at the single neuron level, stimulution of sensory receptors with vibration, biomechanics and motor behavior--all carried out with human subjects. Most research carried out in my laboratory is basic, i.e., investigating sensorimotor control mechanisms, although a portion of our effort is focused on related areas of clinical research (e.g., stroke rehabilitation).
The Spellman Lab is interested in using genetic, genomic, and proteomic data to understand and model the biology of cancer and to develop methods to effectively deploy therapeutic agents in the age of molecularly guided medicine.
Members of the lab use a combination of conventional molecular biology, high throughput genomic and proteomic assays, and bioinformatic analyses in their work.
Dr. Grigsby's research program has evolved through expanded multidisciplinary collaboration among clinician scientists with neonatology and pediatric specialties and basic scientists with expertise in microbiology, reproductive immunology, pathology and cardiovascular physiology. In this regard, her field of research has expanded from preterm birth studies to now include studies on placental development and fetal growth. This research initiative seeks to understand the ability of the developing placental to respond to an adverse in utero environment and to determine the mechanisms underlying placental plasticity which are at the root of the Developmental Origins of Adult Disease phenomenon.
We study mechanotransduction by hair cells, the sensory cells of the inner ear. Being interested in what molecules make up the transduction apparatus, the collection of channels, linker molecules, and motors that mediate transduction, we take a frank reductionist approach. We start with physiology: when you mechanically stimulate a hair cell, what are the characteristics of the resulting receptor current? Studying transduction currents, we learn how transduction channels open and close in response to mechanical forces, and how the adaptation motor responds to sustained forces and allows channels to close. These experiments have suggested candidate families for the transduction channel and the adaptation motors, for example, and we use these clues to identify, clone, and characterize the responsible molecules. Because the scarcity of hair cells prevent extensive biochemical characterization, we express transduction molecules in vitro and determine properties that can be compared with the physiology of transduction. This approach has proven highly successful for identification of the adaptation motor, myosin-1c; the tip link, cadherin-23; and the calcium pump, PMCA2a.
Recently, we have applied proteomics techniques to every aspect of the lab's research program. Modern mass spectrometry is remarkably comprehensive in its ability to identify and quantify molecules and has the sensitivity to detect scarce hair-bundle proteins.
Now that we know the several hundred most abundant proteins of the hair bundle, we can begin to dissect how the hair bundle is assembled during development. Moreover, our knowledge of several proteins of the transduction complex, together with the sensitivity of mass spectrometry, allows us to take a biochemical approach to identification of the transduction channel, one of the central mysteries of the auditory system.
Research interests include "regulation of prokaryotic gene expression and development in response to stress; signal transduction; regulation and mechanism of peptide antibiotic biosynthesis; regulation of genetic competence in Bacillus subtilis."
The goal of the Point-of-Care Engineering Laboratory at OHSU is to develop approaches and technologies that allow early detection and remediation of physical and cognitive decline.
Our interests include:
* Technologies to aid evaluation and remediation of neurological disorders
* Assistive technologies for helping the elderly remain independent
* Modeling of cognitive and motor changes
* Development of unobtrusive sensor technologies
* Integrated management of clinical and sensor data
Research in this lab uses a multitude of engineering approaches, including multi-resolutional signal processing, sophisticated statistical analyses, modeling of physical behaviors of sensors, and computational models of cognitive behaviors. Research spans sensor development to algorithm development to clinical field studies.
The Point of Care Laboratory at OHSU is headed by Misha Pavel, Ph.D. This laboratory also provides the engineering arm of the Oregon Royal Center for Aging and Technology.
The Pathology Services Unit (PSU) provides clinical and anatomic pathology support for disease diagnosis and surveillance for ONPRC’s animal resources.
"Richard Stouffer and his associates investigate the factors controlling the growth and ovulation of the mature follicle at midcycle, as well as development of the corpus luteum from the ovulatory follicle and its function until the end of the menstrual cycle or into early pregnancy. Studies on intact monkeys and research on isolated ovarian tissues and cells are unraveling the complex interaction between substances produced within the ovary (e.g., progesterone and angiogenic factors) and those coming from other organs (gonadotropins from the pituitary gland and placenta) in controlling the ovulatory follicle and corpus luteum.
Stouffer's discovery that progesterone-producing cells within the ovulatory follicle and corpus luteum also contain progesterone receptors led to research identifying an essential role for this steroid hormone within the ovary for follicle rupture and release of the egg, and for development of the corpus luteum. Additional studies are identifying the angiogenic factors (e.g., vascular endothelial growth factor, angiopoietin) that promote the unique development of blood vessels in the adult ovary during the menstrual cycle, and whether aberrant production of these factors is a cause of infertility disorders or side effects during assisted reproductive protocols. These investigations led to ongoing studies in collaboration with other researchers to evaluate the potential of antiprogestins, antiangiogenic agents and inhibitors of oocyte maturation or ovulation as contraceptives in preclinical trials on nonhuman primates.
Stouffer's group is also working with the Assisted Reproductive Technologies (ART) Laboratory and a multi-center Oncofertility Consortium to elucidate the hormonal and local factors critical for normal, timely development of the primate ovarian follicle and its enclosed egg.
This research is directly relevant to continued efforts to improve the clinical approaches to treating infertility and high-risk pregnancy, and to develop new methods of contraception. New information will also aid in the preservation of nonhuman primates through assisted reproductive techniques, such as in vitro fertilization."
Additionally, the Stouffer Lab studies the effects of androgens and Western-style diet on ovarian and uterine function, as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research (SCCPIR).
Dr. Bennett is Professor of Medicine and Nursing at Oregon Health and Science University (OHSU) in Portland, Oregon.
Dr. Lowe conducts health services and clinical epidemiology research in several content areas, reflecting his clinical background as an emergency physician. He has published extensively on the relationship between emergency department use and access to primary care, especially among vulnerable populations. Currently-funded projects include a community-based participatory research project in partnership with Central City Concern; a multi-center consortium conducting clinical trials on treatment of neurological emergencies , and a study on the implementation of electronic medical records in small, rural primary care practices.
We are studying cellular signaling pathways involved in the generation of human cancer. In general, disruption of these pathways alters the ability of a cell to control its proliferation as well as the initiation of programmed cell death (apoptosis). We are focusing on three key signaling pathways that regulate both cellular proliferation and apoptosis: the Myc transcription factor, the Ras signaling protein, and the G1 cyclin dependent kinase (Cdk)/retinoblastoma(Rb)/E2F pathway. While each of these pathways has been extensively studied over the past decade, the nature of their interrelations remains elusive. Since these pathways are deregulated in the majority of all human tumors, we want to understand how they network and synergize to precisely control cellular proliferation versus cell death. This information will contribute to our understanding of the complex nature of cancer progression, and facilitate the generation of meaningful therapies.
Dr. Rugonyi's main research interests include the analysis of biological systems, and the development of mathematical and computational models that describe them. Finite element methods and other numerical techniques, when used with appropriate physically-based models, provide a means of calculating and visualizing the response of systems to different conditions. Dr. Rugonyi's current research is mainly on the study of cardiovascular systems, which includes the analysis of blood flow through vessels and the heart, as well as the interaction of flow with tissue.
Sergio Ojeda and his collaborators seek to understand the process by which the brain controls the initiation of mammalian puberty. An important goal in their laboratory is to gain insights into the molecular and genetic mechanisms underlying deranged sexual development, particularly sexual precocity and delayed puberty of cerebral origin. Ojeda's team focuses on identifying molecules responsible for the interactions that occur between neurons and glial cells in the hypothalamus, a region in the base of the brain that controls several bodily functions, including hormone secretion, reproduction, response to stress, feeding and sex behavior. One group of hypothalamic neurons produces gonadotropin-releasing hormone (GnRH), a substance that controls the secretion of reproductive hormones from the pituitary gland.
The investigators are using cellular, molecular, genetics and systems biology strategies, in addition to high-throughput approaches and computational biology methods to develop three interrelated concepts: 1) That mammalian puberty is controlled by genetic networks that, operating within different cell contexts in the neuroendocrine brain, coordinate the activity of GnRH neurons at puberty, 2) That these networks are controlled at the transcriptional level by a repressive mechanism exerted by discrete subsets of gene "silencers", and 3) That this transcriptional regulation is under epigenetic control, i.e. a mechanism by which environmental factors (such as nutrition, man-made chemicals, changes in light/dark cycle, etc.) regulate gene activity without modifying the actual sequence of encoding DNA.
The Morrison lab's research uses electrophysiological and anatomical approaches to understand the functional organization, rhythmicities, developmental influences and pharmacology of the CNS circuits that regulate the sympathetic outflows controlling variables critical for homeostasis such as body temperature, energy expenditure, blood glucose, blood pressure, cardiac output and plasma catecholamines.
Prof. Jacques and his team are interested in biomedical optics and laser-tissue interactions. Additionally, their work involves the development of diagnostic and therapeutic devices for medicine and biology using optical technologies.
Individuals who have a history of drug use are more impulsive than individuals who do not have such a history. My research examines whether this difference existed prior to drug use, or is a consequence of the neuroadaptations due to drug use. To address these questions, we work with human, rat and mouse subjects. For example, we examine whether different genotypes are associated with impulsive behavior by comparing impulsivity in drug-naïve selected lines and inbred strains of mice and rats. Also we examine whether different levels of impulsivity predict responses the first time mice and rats are exposed to drugs of abuse, like alcohol, nicotine and methamphetamine. Measures of impulsivity in human subjects are used to examine whether acute exposure to drugs of abuse or withdrawal form use results in changes in behavior. In addition, my research examines the basic neural processes involved in decision making, including impulsive and risky decision making, using lesion techniques and imaging.
We develop and apply imaging nanotechnologies to study cellular signaling in health and disease.
Our basic research thrust is to develop molecular-scale quantitative imaging tools to understand the spatiotemporal dynamics of cellular signaling in the nervous system. Our applied research thrust is to develop new technologies to identify and assess drug effectiveness in cancer and neurodegenerative diseases.
Areas of special interest include the hormonal effects on pelvic floor connective tissue, epidemiology of pelvic floor dysfunction, and pelvic floor injury.
Dr. Unni has a special interest in taking care of people with Parkinson’s Disease and other disorders of movement. He has specific training in both the patient-care side and research aspects of these disorders. He enjoys treating people with these types of problems and working to make their lives better using the kind of team approach that is possible at OHSU.
Our research program employs functionalized nanomaterials in biomedical devices and medicine. Our laboratory is a part of the Department of Biomedical Engineering, Oregon Health Science University (OHSU) School of Medicine. Our research involves development of animal models of kidney and metal-related diseases and applying the nanomaterials to diagnose, prevent, or treat such diseases.
Research interests broadly include machine learning and computer vision areas with the main focus on medical image registration and analysis.
Found 69 laboratories .