eagle-i Oregon Health and Science UniversityOregon Health and Science University
See it in Search

Women's Health Research Unit

Affiliations:

People:

Resources:

Instruments

Protocols

  • Anal ultrasound ( Protocol )

    Protocol used to study anal incontinence.

  • Cervical mucus evaluation protocol ( Protocol )

    A gynecologic speculum exam is completed to view the cervix. Cervical mucus is collected by aspiration using the SelectMucus® Endocervical Aspirator (Cooper Surgical or similar). Cervical mucus score is based on the modified Insler scoring system (the volume and pH of the mucus are not included in the total scoring) yielding a total possible modified Insler score of 12. The subject’s cervical mucus result is totaled and documented per study protocol.

  • Endometrial biopsy protocol ( Protocol )

    Collection of Endometrial biopsies: The subject will be placed in lithotomy on a GYN examination table and a bimanual exam will be performed to confirm uterine position. An Explora (CooperSurgical or similar) FDA-approved vacuum suction biopsy device will be used to collect all samples using standard technique described as follows: Following an antiseptic wash (betadine or hibiclens) of the cervix, the biopsy curette will be passed through the cervix to the uterine fundus, the vacuum syringe will be attached, and a brief curettage preformed. For analgesia, subjects may elect to receive intrauterine lidocaine 2% solution, 5cc, delivered through the biopsy curette prior to the curettage procedure. If the curette cannot be passed easily, a paracervical block of 1% lidocaine (10 cc) will be administered, followed by placement of a tenaculum, and sequential cervical dilation as needed. Following collection, the specimen samples will immediately be placed in formalin and transported to the location specified in the protocol for further processing.

  • Endometrial thickness (ultrasound) protocol ( Protocol )

    The endometrium is evaluated in the AP plane. A measurement is obtained at the point of maximal thickness. Any abnormalities will be recorded. Images will be recorded as required by the protocol.

  • Hormone evaluation protocol ( Protocol )

    Blood samples are drawn from the patient and processed/stored/shipped per study protocol.

    We have the following capabilities:
    • Determine cycle timing for hormone evaluation (as required by study protocol).
    • Draw specimen sample (i.e., phlebotomy).
    • Process (i.e., centrifuge) and separate as needed.
    • Store (room temperature, refrigerator, -20° freezer or -80° freezer).
    • Ship (within OHSU campus, nationally, internationally) according to federally recognized shipping standards.

  • Multichannel urodynamics protocol ( Protocol )

    Protocol used to study bladder dysfunction.

  • Ovarian follicle monitoring protocol ( Protocol )

    The ovaries will be evaluated in both the AP and transverse planes. The overall ovarian size will be obtained in the two planes. Images will be recorded as required by the protocol. Both ovaries will be assessed.

    Antral follicle count: If required by the protocol, the entire ovary will be assessed in one plane and the number of follicles >/= 4 mm (or the size determined by protocol) will be recorded. The maximal diameter and mean (average of 2 dimensions in one plane) will be recorded. Images will be recorded as required by the protocol. The ovary will then be assessed in the opposite plane. The total number of follicles will be counted in the plane that best represents the ovary.

    Dominant follicle: If required by the protocol, the entire ovary will be assessed in one plane and the maximum diameter and mean (average of 2 dimensions in one plane) diameter of the largest follicle will be recorded. Images will be recorded as required by the protocol.

    Follicle rupture. Depending on the protocol, follicle growth and rupture may be a study endpoint. Follicle rupture will be defined as a size of the dominant follicle associated with a change in architecture and internal echoes.

  • Pelvic floor ultrasound protocol ( Protocol )

    Protocol used to study pelvic floor disorders.

  • Pelvic ultrasound protocol ( Protocol )

    Transvaginal ultrasound is performed to access the pelvic organs including the ovaries, ovarian follicles, uterine corpus, uterine cervix and endometrium. Detailed descriptions will be obtained per the specific requirements of the research protocol. This summary refers to the general approach to vaginal ultrasound.


    The transvaginal ultrasound is performed using a GE Voluson-i ultrasound equipped with an 8 mHz vaginal transducer. The ultrasound transducer is cleaned and cold sterilized after each use. Prior to each use, the probe is covered with an ultrasound sheath. A small amount of ultrasound coupling gel is placed inside the sheath prior to placement over the probe. Additional lubricant is placed on top of the sheath prior to insertion into the vagina.

  • Thrombosis markers protocol ( Protocol )

    Blood samples are drawn from the patient and processed/stored/shipped per study protocol.

    We have the following capabilities:
    • Draw specimen sample (i.e., phlebotomy).
    • Process (i.e., centrifuge) and separate as needed.
    • Store (room temperature, refrigerator, -20° freezer or -80° freezer).
    • Ship (within OHSU campus, nationally, internationally) according to federally recognized shipping standards.

  • Vaginal biopsy protocol ( Protocol )

    A speculum exam will be performed to visualize the vagina & cervix. Topical lidocaine gel will be applied to the lateral vaginal fornices. After 2 minutes, betadine will be applied and two full thickness 2 x 4 mm biopsies will be obtained using a Baby Tischler forceps. Biopsies will be obtained from sites indicated by protocol. The tissue samples will immediately be placed in formalin and transported to the location specified in the protocol for further processing.

Services

  • Women's health study support service ( Support service )

    Support services include:

    - Subject recruitment and enrollment service
    - Conduct of Phase I - IV clinical trials consultation
    - Data collection and analysis
    - Human subjects regulatory (IRB) service
    - Manuscript preparation support
    - Protocol development


Web Links:

Last updated: 2011-05-11T17:20:02.404-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016