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Neuropathology Core

Summary:

The Neuropathology Core of the Layton Center for Aging and Alzheimer’s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer’s Disease Center Clinical Core.

Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.

Affiliations:

People:

Resources:

Biological Specimens

  • Human brain specimens ( Biological Specimen )

    "Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment."

Protocols

  • Human brain dissection and tissue fixation protocol ( Protocol )

    Midfrontal gyrus
    Inferior parietal lobule
    Posterior superior temporal gyrus
    Primary visual cortex
    Hippocampus (rostral to caudal)
    Amygdala
    Putamen (1 precommissural, 1 at anterior commissure, 1 postcommissural)
    Globus pallidus (1 precommissural, 1 at anterior commissure, 1 postcommissural)
    Caudate (1 precommissural, 1 at anterior commissure, 1 postcommissural)
    Midbrain (rostral to caudal)
    Pons (rostral to caudal with first including the locus ceruleus)
    Medulla (rostral to caudal)
    Cerebellar cortex
    right mid frontal gyru
    left mid frontal gyrus
    frontal lobe white matter (1cm anterior to lat vent)
    right inferior parietal lobule
    left inferior parietal lobule
    right superior and middle temporal gyrus
    left superior and middle temporal gyrus
    anterior cingulate gyrus
    right primary visual cortex
    left primary visual cortex
    hippocampus at level of uncus
    hippocampus at the level of the lateral geniculate
    amygdala right
    striatum at the level of the anterior commissure
    left striatum at the level of the anterior commissure
    right thalamus
    left thalamus
    midbrain with substantia nigra
    pons
    medulla
    cerebellar cortex
    spinal cord/pituitary (as available)

Services

  • Access to human brain biospecimens ( Access service )

    "Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies."

    Autopsy reports can be provided.

  • Human brain dissection and histological sample preparation training ( Training service )

    "In most cases, 22 sections are taken following formalin fixation from all lobes of the left and right hemispheres, the white matter, deep gray structures, brainstem, cerebellum and spinal cord (as available). The sections are routinely stained with hematoxylin and eosin / Luxol fast blue, Bielschowski silver staining, Congo Red, and for hyperphosphorylated tau and a-synuclein by immunohistochemistry."

  • Training in current methods of neuropathological classification of neurodegenerative diseases and age-related changes ( Training service )

    List of anatomical terms:

    Midfrontal gyrus Inferior parietal lobule Posterior superior temporal gyrus Primary visual cortex Hippocampus (rostral to caudal) Amygdala Putamen (1 precommissural 1 at anterior commissure 1 postcommissural) Globus pallidus (1 precommissural 1 at anterior commissure 1 postcommissural) Caudate (1 precommissural 1 at anterior commissure 1 postcommissural) Midbrain (rostral to caudal) Pons (rostral to caudal with first including the locus ceruleus) Medulla (rostral to caudal) Cerebellar cortex

    List of diseases:

    * Alzheimer Disease,
    * Healthy controls
    * frontotemporal dementia
    * Lewy body dementia
    * Parkinson's disease
    * Huntington's disease
    * multiple system atrophy
    * ALS
    * other encephalopathies


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Last updated: 2012-07-16T16:09:03.188-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016