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Methamphetamine Abuse Research Center Animal Core Component

Director: Crabbe, John C., Ph.D.

Summary:

Three of the MARC's research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center.

The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization.

In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize.

Affiliations:

People:

Resources:

Databases

  • Animal tracking database ( Database )

    Database is for tracking mouse identity and trait data for Methamphetamine Abuse Research Center (MARC) scientists for work on MARC Component Projects.

Organisms and Viruses

  • C57BL/6J ( Mus musculus )

    The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6). The animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine, drinking and for high and low methamphetamine-induced sensitization.

  • DBA/2J ( Mus musculus )

    The core will breed special mouse lines F1 and F2 that are descendents of DBA/2J (D2). The animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine, drinking and for high and low methamphetamine-induced sensitization.

Services

  • Behavioral testing procedures service ( Training service )

    Service is meant to assist MARC Researchers with mouse tests of methamphetamine consumption and methamphetamine sensitization. Assistance with experimental design, protocol, data handling is also available.

  • Database service for tracking mice and posting trait data ( Material analysis service )

    Service is for tracking mouse identity and trait data for Methamphetamine Abuse Research Center (MARC) scientists for work on MARC Component Projects.

  • Mice maintenance service ( Material storage service )

    "Three of the MARC's research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center.

    The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization.

    In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize."

  • Mice purchasing service ( Access service )

    Service includes assistance in purchasing mice for Methamphetamine Abuse Research Center (MARC) scientists for work in MARC Component Projects.

  • Mouse breeding ( Material production service )

    "The Animal Core will breed special mouse lines, F1 and F2 crosses that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For MARC Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization."

  • Mouse breeding service ( Material production service )

    "The Animal Core will breed special mouse lines, from F2 crosses that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For MARC Components 5 and 6, the animal core will selectively breed independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization."

  • Mouse distribution service ( Access service )

    "Three of the MARC's research components (5, 6, and 8) include experiments with lines of mice bred to have special genetic traits. The animal core supports these components by purchasing, testing, breeding, maintaining, and distributing these animals within the center.

    The core will breed special mouse lines F1 and F2 that are descendents of C57BL/6J (B6) and DBA/2J (D2) inbred strains. For Components 5 and 6, the animal core will also produce independent sets of replicated mouse lines selected for high and low tendencies toward methamphetamine drinking and for high and low methamphetamine-induced sensitization.

    In addition, the core is developing new behavioral-testing procedures and maintaining a database that will track individual animals and post their trait data for all MARC investigators to utilize."


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Last updated: 2011-05-11T14:12:24.585-05:00

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