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Leslie Muldoon Laboratory

Summary:

Dr. Muldoon has extensive background in tumor and cell biology, magnetic resonance imaging, and histological and immunological methods for assessing neurotoxicity and tumor volumetrics. She has played a central role in the analysis of chemoprotective agents against chemotherapy toxicity, and the development and imaging of brain tumor models.

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Organisms and Viruses

  • Nude rats ( Rattus norvegicus )

    Rat models are used for models of human brain tumors. All tumor models use nude rats housed in the animal facilities at OHSU Comparative Medicine.

    1. Implanted primary brain tumors – caudate or cerebellum location
    Glioma (U87MG, UW28, U251)
    Medulloblastoma (DAOY, D283-Med)
    B-Cell lymphoma (MC116)
    Oligodendroglioma (Hs683)

    2. Implanted metastatic brain tumors
    Breast cancer (MDA-MB231BR-HER2, and many other MDA-MB231BR clones with high or low HER2, GFP, fluc)
    Melanoma (A2058, A375)
    Lung cancer (LX-1 SCLC, H460 large cell NSCLC, A549 adenocarcinoma, H520 squamous cell)

    3. Hematogenous brain metastases, cells infused into the internal carotid artery
    Breast cancer (MDA-MB231BR-HER2)
    Melanoma (A2058)
    Lung cancer (H460 large cell NSCLC, A549 adenocarcinoma)

    4. Leptomeningeal tumors, cells infused into cerebral ventricle or cisterna magna
    Medulloblastoma (DAOY, D283-Med)
    Breast cancer (MDA-MB231BR-HER2)
    B-Cell lymphoma (MC116)

    5. Intraperitoneal (abdominal cavity)
    Ovarian ( SKOV3)

    6. Subcutaneous
    Neuroblastoma (SK-N-AS)
    Many of the cell lines listed above can grow SQ tumors.

Reagents


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Last updated: 2013-06-14T14:23:41.918-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016