Adk-Tg (fb-Adk-def)

eagle-i ID

Resource Type

Properties

1. Related Disease

   Alzheimer's disease

2. Related Disease

   Parkinson's disease

3. Related Disease

   epilepsy syndrome

4. Related Disease

   schizophrenia

5. Related Publication or Documentation

   Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.

6. Related Publication or Documentation

   A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors.

7. Related Publication or Documentation

   Adenosine kinase determines the degree of brain injury after ischemic stroke in mice.

8. Related Publication or Documentation

   Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.

9. Parental Strain Name

   C57BL/6

10. Genetic Alteration(s)

    Adenosine Kinase knockout

11. Genetic Alteration(s)

    Adenosine kinase transgene (human ubiquitin promoter)

12. Phenotype Findings

    Spontaneous electrographic seizures

13. Phenotype Findings

    Cognitive impairment

14. Phenotype Findings

    Reduced responsiveness to amphetamine

15. Phenotype Findings

    Schizophrenia-related endophenotypes

16. Location

    Detlev Boison Laboratory