Research Cytogenetics Core Laboratory

Summary:

A fee-for-service cytogentics laboratory available to genetics researchers to assist in development and execution of cytogenetics experiments for research purposes. Through rigorous standardization of protocols and customized experiment development, the OHSU Research Cytogenetics Core Laboratory provides high quality metaphase and interphase cytogenetic data to the OHSU research community. Services are also available to non-profit and commercial investigators located in Oregon and elsewhere.

Affiliations:

• Department of Molecular & Medical Genetics, Oregon Health & Science University

People:

• PI: Olson, Susan B., Ph.D.
  

Resources:

Services

• Chromosome breakage and radial formation analysis ( Material analysis service )
  

  Various DNA damaging agents, including:
  
  - Mitomycin C (MMC)
  - Diepoxybutane (DEB)

• Consultation on research design, grant preparation, and manuscript preparation ( Support service )
  

• Fluorescent in situ hybridization ( Material analysis service )
  

  Service includes:
  * Probe Development (multi-species)
  * Probe design consultation
  * BAC preparation
  * Probe Localization
  * Interphase Mapping
  * Cell-Cell Fusion
  * FISH following immunocytochemistry
  * Ploidy assessment
  * Commercial FISH probe analysis
  * Others by request

• G-banded karyotyping ( Material analysis service )
  

  High resolution G-banded analysis

• Mentoring in cytogenetics ( Training service )
  

• Mitotic index service ( Material analysis service )
  

• Ploidy/Aneuploidy Assessment ( Material analysis service )
  

• Sister chromatid exchange service ( Material analysis service )