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|  Oregon Health and Science University |
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| Oregon Health and Science University |
The Neuropathology Core of the Layton Center for Aging and Alzheimer’s Disease Center is dedicated to studying, through autopsy, the brains of individuals who have been followed longitudinally in the Oregon Alzheimer’s Disease Center Clinical Core.
Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment.
"Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies. Material Transfer Agreements between the requesting and sending institutions are needed before shipment."
Midfrontal gyrus
Inferior parietal lobule
Posterior superior temporal gyrus
Primary visual cortex
Hippocampus (rostral to caudal)
Amygdala
Putamen (1 precommissural, 1 at anterior commissure, 1 postcommissural)
Globus pallidus (1 precommissural, 1 at anterior commissure, 1 postcommissural)
Caudate (1 precommissural, 1 at anterior commissure, 1 postcommissural)
Midbrain (rostral to caudal)
Pons (rostral to caudal with first including the locus ceruleus)
Medulla (rostral to caudal)
Cerebellar cortex
right mid frontal gyru
left mid frontal gyrus
frontal lobe white matter (1cm anterior to lat vent)
right inferior parietal lobule
left inferior parietal lobule
right superior and middle temporal gyrus
left superior and middle temporal gyrus
anterior cingulate gyrus
right primary visual cortex
left primary visual cortex
hippocampus at level of uncus
hippocampus at the level of the lateral geniculate
amygdala right
striatum at the level of the anterior commissure
left striatum at the level of the anterior commissure
right thalamus
left thalamus
midbrain with substantia nigra
pons
medulla
cerebellar cortex
spinal cord/pituitary (as available)
"Requests for tissue from the Oregon Brain Bank should be directed to Dr. Randall Woltjer. Dr. Woltjer will be glad to communicate with investigators regarding their tissue needs and to assist them in identifying suitable materials for their studies."
Autopsy reports can be provided.
"In most cases, 22 sections are taken following formalin fixation from all lobes of the left and right hemispheres, the white matter, deep gray structures, brainstem, cerebellum and spinal cord (as available). The sections are routinely stained with hematoxylin and eosin / Luxol fast blue, Bielschowski silver staining, Congo Red, and for hyperphosphorylated tau and a-synuclein by immunohistochemistry."
List of anatomical terms:
Midfrontal gyrus Inferior parietal lobule Posterior superior temporal gyrus Primary visual cortex Hippocampus (rostral to caudal) Amygdala Putamen (1 precommissural 1 at anterior commissure 1 postcommissural) Globus pallidus (1 precommissural 1 at anterior commissure 1 postcommissural) Caudate (1 precommissural 1 at anterior commissure 1 postcommissural) Midbrain (rostral to caudal) Pons (rostral to caudal with first including the locus ceruleus) Medulla (rostral to caudal) Cerebellar cortex
List of diseases:
* Alzheimer Disease,
* Healthy controls
* frontotemporal dementia
* Lewy body dementia
* Parkinson's disease
* Huntington's disease
* multiple system atrophy
* ALS
* other encephalopathies