The Oregon Stem Cell Center conducts basic and applied research in the field of Stem Cell Biology with the long term goal to harness the properties of stem cells for regenerative medicine and cell therapy.
The Oregon Stem Cell Center was created on January 1, 2004 and is directed by Markus Grompe, M.D. The center is housed on the top (7th) floor of the Biomedical Research Building. In 2009, the center administratively became part of the Papé Family Pediatric Research Institute.
The OSCC has 3 cores, a monoclonal antibody production core, a cell sorting core and a cell isolation core. Philip Streeter, Ph.D. is the director of these core laboratories. The main goal of the cores is to generate novel reagents for the isolation of stem cells and their differentiated offspring by generating monoclonal antibodies directed against cell surface antigens of living cells. The cell sorting core uses a state-of-the-art Cytopeia high speed InFlux instrument and is capable of sorting large and fragile cells without loss of viability. The cell isolation core will provide cell isolations services including tissue procurement and protease digestion of these tissues.
The Oregon Stem Cell Center Monoclonal Antibody Core is focused on developing monoclonal antibodies that aid investigators in the identification and isolation of novel stem and progenitor cell populations. To enable isolation of live stem cells, personnel within the Monoclonal Antibody Core develop monoclonal antibodies directed against cell surface antigens. Personnel within the laboratory are highly skilled in all aspects of monoclonal antibody generation and characterization, and work closely with investigators throughout the entire immunization, fusion, and screening process. The monoclonal antibody core offers a full complement of services related to the development of monoclonal antibodies.